在18号染色体上寻找精神分裂症易感基因。

Search for a schizophrenia susceptibility gene on chromosome 18.

作者信息

Fang N, Coon H, Hoff M, Holik J, Hadley D, Reimherr F, Wender P, Myles-Worsley M, Waldo M, Freedman R

机构信息

Department of Psychiatry, University of Utah Medical Center, Salt Lake City 84132, USA.

出版信息

Psychiatr Genet. 1995 Spring;5(1):31-5. doi: 10.1097/00041444-199521000-00005.

DOI:10.1097/00041444-199521000-00005

PMID:7582878

Abstract

Nine multiplex schizophrenia families were genotyped with 15 microsatellite markers mapping to the short and long arm of chromosome 18. Assuming either autosomal dominant or recessive inheritance evidence of linkage was not found. In addition, the non-parametric sib pair test did not reveal significant evidence of linkage.

摘要

对9个多重精神分裂症家系进行了基因分型，使用了15个微卫星标记，这些标记定位于18号染色体的短臂和长臂。假设为常染色体显性或隐性遗传，均未发现连锁证据。此外，非参数同胞对检验也未显示出显著的连锁证据。