家族性精神分裂症一个主要易感基因座位于1号染色体1q21 - q22区域。
Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22.
作者信息
Brzustowicz L M, Hodgkinson K A, Chow E W, Honer W G, Bassett A S
机构信息
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA.
出版信息
Science. 2000 Apr 28;288(5466):678-82. doi: 10.1126/science.288.5466.678.
Abstract
Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.
摘要
精神分裂症是一种复杂的疾病，有大量证据支持其遗传病因。尽管如此，先前定位易感基因座的尝试主要产生了提示性的结果。对22个精神分裂症发病率高的大家庭进行的全基因组扫描，为与1号染色体（1q21-q22）的连锁提供了高度显著的证据，连锁可能性对数（lod）得分的最大异质性为6.50。这一连锁结果应提供足够的能力，以便对潜在的易感基因进行定位克隆。
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A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci.在芬兰一个孤立亚群体中对精神分裂症基因进行全基因组筛查，提示存在多个易感基因座。
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