Ogawa S, Yu Y
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Bioorg Med Chem. 1995 Jul;3(7):939-43. doi: 10.1016/0968-0896(95)00079-v.
Mannostatins A and B, along with the respective enantiomer and diastereoisomer having the (S)-sulfinyl function, were synthesized from myo-inositol. Inhibitory activity of the synthetic compounds against jack bean alpha-mannosidase was measured, revealing that the 4-aminocyclopentane-1,2,3-triol structure plays a major role in interaction with the enzyme.
