Wilkie A O, Morriss-Kay G M, Jones E Y, Heath J K
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
Curr Biol. 1995 May 1;5(5):500-7. doi: 10.1016/s0960-9822(95)00102-3.
Fibroblast growth factors were first characterized twenty years ago as mitogens of cultured fibroblasts. Despite a wealth of data from experiments in vitro, insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their receptors.