Diana G, Domenici M R, Scotti de Carolis A, Loizzo A, Sagratella S
Laboratorio di Farmacologia, Istituto Superiore di Sanita, Roma, Italy.
Brain Res. 1995 Jul 17;686(1):107-10. doi: 10.1016/0006-8993(95)00440-2.
Expression of Ca(2+)-induced CA1 long-term potentiation (LTP) was analysed in hippocampal slices obtained from (1) 3-month-old and (2) 18-20-month-old Sprague-Dawley rats selected for their performances in the Morris water maze task. In all slices, a transient (10 min) increase of extracellular Ca2+ concentration (4 mM) caused a long-lasting enhancement of potentials evoked by electrical stimulation of radiatum fibers. However, a significant difference was found in the degree of potentiation among groups. In particular, increases of the CA1 response amplitudes were significantly lower in old rats impaired in spatial learning than in young at 30 (P < 0.05), 60, 90 and 120 min (P < 0.01) after restoring the normal Ca2+ concentration. On the contrary, no differences were observed between young animals and the old ones with good performances in spatial learning. The data suggest that amplitude of CA1 Ca(2+)-induced LTP in old rats is related to spatial learning abilities.
在从以下两组大鼠获取的海马切片中分析了钙诱导的CA1长时程增强（LTP）的表达：（1）3个月大的和（2）18 - 20个月大的Sprague-Dawley大鼠，这些大鼠是根据它们在莫里斯水迷宫任务中的表现挑选出来的。在所有切片中，细胞外钙浓度短暂（10分钟）升高至4 mM会导致由辐射层纤维电刺激诱发的电位出现持久增强。然而，各组之间在增强程度上发现了显著差异。具体而言，在恢复正常钙浓度后30分钟（P < 0.05）、60分钟、90分钟和120分钟时，空间学习受损的老年大鼠中CA1反应幅度的增加显著低于年轻大鼠（P < 0.01）。相反，在空间学习中表现良好的年轻动物和老年动物之间未观察到差异。数据表明，老年大鼠中CA1钙诱导的LTP幅度与空间学习能力有关。
