Wallois F, Gros F, Masmoudi K, Larnicol N
Laboratoire de Neurophysiologie, CNRS URA 1331, UFR de Médecine, Université de Picardie, Amiens, France.
Brain Res. 1995 Jul 31;687(1-2):143-54. doi: 10.1016/0006-8993(95)00487-b.
Sneeze is one of the most important protective reflex of the respiratory tract. It is elicited from trigeminal peripheral fields and results in major changes in the discharge patterns of the medullary respiratory-related neurons. The pattern of c-Fos-like immunoreactivity evoked by sneezing was explored as a structural approach to the networks involved in this particular model of trigemino--respiratory interactions. Sneezes were elicited in anaesthetized adult cats by driving air puffs to the superior nasal meatus through a catheter. Additional cats were used as controls for anaesthesia and for catheter insertion into the nostril. In sneezing cats, immunoreactivity was evoked in projection areas of the ethmoidal afferents which innervate the superior nasal meatus, e.g. the subnuclei caudalis, interpolaris and in the interstitial islands of the trigeminal sensory complex. Immunoreactivity was also markedly enhanced in the areas devoted to respiratory control in the medulla (solitary complex, nucleus retroambiguus) and in the pontine parabrachial area. C-Fos expression was also evoked in the lateral aspect of the parvicellular reticular formation in sneezing cats. This area might be of major importance in the adaptation of the ventilatory system to expulsive functions.
打喷嚏是呼吸道最重要的保护性反射之一。它由三叉神经外周区域引发，并导致延髓呼吸相关神经元放电模式的重大变化。作为一种研究参与这种特定三叉神经 - 呼吸相互作用模型的神经网络的结构方法，我们探索了打喷嚏诱发的c-Fos样免疫反应模式。通过导管将气流吹入成年麻醉猫的上鼻道来诱发打喷嚏。另外的猫用作麻醉和将导管插入鼻孔的对照。在打喷嚏的猫中，支配上鼻道的筛骨传入纤维的投射区域，如尾侧亚核、极间亚核以及三叉神经感觉复合体的间质岛中诱发了免疫反应。延髓中负责呼吸控制的区域（孤束复合体、疑核后核）以及脑桥臂旁区域的免疫反应也明显增强。在打喷嚏的猫中，小细胞网状结构的外侧也诱发了c-Fos表达。该区域在通气系统适应呼气功能方面可能具有重要意义。
