Wang J S, Jen C J, Chen H I
Department of Physiology, National Cheng-Kung University Medical College, Tainan, Taiwan, ROC.
Arterioscler Thromb Vasc Biol. 1995 Oct;15(10):1668-74. doi: 10.1161/01.atv.15.10.1668.
Platelets play an important role in the pathogenesis of cardiovascular disease. It has also been noticed that regular exercise can reduce the risk of cardiovascular disease. This is the first study to demonstrate that endurance exercise training may suppress platelet adhesiveness and aggregation and that deconditioning may reverse the training effects. Healthy male sedentary subjects were randomly divided into control and training groups. The trained men were trained on a bicycle ergometer at about 60% of maximal oxygen consumption for 30 minutes per day, 5 days per week for 8 weeks, then deconditioned for 12 weeks. During the experimental period, blood samples of the trained subjects were collected before and immediately after a progressive exercise test every 4 weeks. The same experiments were applied to the controls at the beginning of this study and 8 weeks thereafter. A tapered parallel-plate chamber was used to assess platelet adhesiveness. Platelet aggregation induced by ADP was evaluated by the percentage of reduction in single platelet count. Our results showed that (1) platelet adhesiveness and aggregability were increased by short-term strenuous exercise in both control and trained groups, but the enhancement of platelet aggregability was decreased after exercise training in the trained subjects; (2) at rest and immediately after strenuous exercise, platelet adhesiveness and aggregability were decreased by training, whereas they were unchanged in the control group; and (3) deconditioning reversed the training effects on resting and postexercise platelet adhesiveness and aggregability back to the pretraining state. These results suggest that platelet adhesiveness and aggregability may be depressed by exercise training but be reversed back to the pretraining state after deconditioning.
血小板在心血管疾病的发病机制中起着重要作用。人们还注意到，经常锻炼可以降低心血管疾病的风险。这是第一项证明耐力运动训练可能会抑制血小板黏附性和聚集性，而失体能状态可能会逆转训练效果的研究。健康的久坐不动的男性受试者被随机分为对照组和训练组。训练组的男性在自行车测力计上以最大耗氧量的60%左右进行训练，每天30分钟，每周5天，持续8周，然后进行12周的失体能状态处理。在实验期间，每4周在渐进性运动试验前和试验后立即采集训练组受试者的血样。在本研究开始时和之后8周，对对照组进行相同的实验。使用锥形平行板腔室评估血小板黏附性。通过单个血小板计数减少的百分比评估ADP诱导的血小板聚集。我们的结果表明：（1）在对照组和训练组中，短期剧烈运动均会增加血小板黏附性和聚集性，但训练组受试者运动训练后血小板聚集性的增强程度降低；（2）在休息时和剧烈运动后立即测量，训练会降低血小板黏附性和聚集性，而对照组则无变化；（3）失体能状态使训练对休息时和运动后血小板黏附性和聚集性的影响逆转回训练前状态。这些结果表明，运动训练可能会降低血小板黏附性和聚集性，但在失体能状态后会逆转回训练前状态。
