Kochoyan M, Leroy J L
Groupe de Biophysique de l'Ecole Polytechnique et de l'Unité de Recherche Associée, Centre Nationale de La Recherche Scientifique, Palaiseau, France.
Curr Opin Struct Biol. 1995 Jun;5(3):329-33. doi: 10.1016/0959-440x(95)80094-8.
Of particular interest among the revelations from recent new DNA structures is the finding that both strands of the repeated DNA sequences found in telomeres and centromeres may adopt alternative conformations. High-definition NMR studies yielded information on the residence time of the water molecules interacting with nucleic acids. A better knowledge of the residence time of the hydration water may be useful in assessing its contribution to nucleic acid structure.
近期新的DNA结构所揭示的内容中,特别值得关注的是在端粒和着丝粒中发现的重复DNA序列的两条链都可能呈现出不同的构象。高分辨率核磁共振研究得出了与核酸相互作用的水分子停留时间的信息。更好地了解水合水的停留时间可能有助于评估其对核酸结构的贡献。