De Mesmaeker A, Altmann K H, Waldner A, Wendeborn S
Central Research Laboratories, Ciba-Geigy Ltd, Basel, Switzerland.
Curr Opin Struct Biol. 1995 Jun;5(3):343-55. doi: 10.1016/0959-440x(95)80096-4.
In the past year major advances have been made in the design, synthesis and characterization of two classes of modified oligonucleotides. In the first class, the phosphodiester backbone of 2'-deoxyribo-oligonucleotides has been replaced in several different ways. The second group represents a completely different type of oligonucleotide modification in which the backbone and the 2'-deoxyribose moieties are replaced by amino acids. These advances present new possibilities for the pharmaceutical applications of modified oligonucleotides in antisense strategies.
在过去的一年里，两类修饰寡核苷酸的设计、合成及特性研究取得了重大进展。在第一类中，2'-脱氧核糖寡核苷酸的磷酸二酯主链已通过几种不同方式被取代。第二类代表了一种完全不同类型的寡核苷酸修饰，其中主链和2'-脱氧核糖部分被氨基酸取代。这些进展为修饰寡核苷酸在反义策略中的药物应用带来了新的可能性。
