Bansal M, Bhattacharyya D, Vijaylakshmi S
Molecular Biophysics Unit, Indian Institute of Science, Bangalore.
Comput Appl Biosci. 1995 Jun;11(3):289-92. doi: 10.1093/bioinformatics/11.3.289.
The NUVIEW software package allows skeletal models of any double helical nucleic acid molecule to be displayed on a graphics monitor and to apply various rotations, translations and scaling transformations interactively, through the keyboard. The skeletal model is generated by connecting any pair of representative points, one from each of the bases in the basepair. In addition to the above mentioned manipulations, the base residues can be identified by using a locator and the distance between any pair of residues can be obtained. A sequence based color coded display allows easy identification of sequence repeats, such as runs of Adenines. The real time interactive manipulation of such skeletal models for large DNA/RNA double helices, can be used to trace the path of the nucleic acid chain in three dimensions and hence get a better idea of its topology, location of linear or curved regions, distances between far off regions in the sequence etc. A physical picture of these features will assist in understanding the relationship between base sequence, structure and biological function in nucleic acids.
NUVIEW软件包允许在图形监视器上显示任何双螺旋核酸分子的骨架模型，并通过键盘交互式地应用各种旋转、平移和缩放变换。骨架模型是通过连接任意一对代表点生成的，每个碱基对中的一个碱基各取一个代表点。除上述操作外，还可以使用定位器识别碱基残基，并获得任意一对残基之间的距离。基于序列的颜色编码显示便于识别序列重复，如腺嘌呤连续序列。对大型DNA/RNA双螺旋的此类骨架模型进行实时交互式操作，可用于在三维空间中追踪核酸链的路径，从而更好地了解其拓扑结构、线性或弯曲区域的位置、序列中远距离区域之间的距离等。这些特征的直观图像将有助于理解核酸中碱基序列、结构和生物学功能之间的关系。
