Cook N R, Albert M S, Berkman L F, Blazer D, Taylor J O, Hennekens C H
Department of Medicine, Brigham and Women's Hospital, USA.
J Gerontol A Biol Sci Med Sci. 1995 Nov;50(6):M317-23. doi: 10.1093/gerona/50a.6.m317.
Peak expiratory flow rate (PEFR) is correlated with several measures of health in the elderly, including physical and cognitive function. It is unclear, however, whether these relationships persist among the non-frail.
The Community-based Studies of the MacArthur Foundation Research Network on Successful Aging included measures of PEFR using a mini-Wright peak flow meter on a sample of 1,354 subjects selected from those aged 70-79 in three population samples. Subjects were chosen on the basis of simple measures of physical and cognitive function (high = 1192; medium = 80; low = 82), and were given a series of more detailed tests.
Residual PEFR, adjusted for age, sex, height, weight, and smoking, was highly correlated (p < .001) with several physical performance measures, including number of steps in a tandem walk, number of seconds in a single leg stand, times to turn in a circle, write one's name, and walk 10 feet at a fast pace, foot-tapping (time per tap), and hand grip strength. The strongest association was evident for a combination of six physical function items. Residual PEFR was also correlated with cognitive performance, including tests of similarities, naming, spatial recognition, memory, and figure drawing. The strongest association was present for a combined measure. These associations persisted in analyses restricted to those in the "high" function group as well as with no history of previous myocardial infarction, stroke, or cancer. Residual PEFR also exhibited a strong independent association with urinary norepinephrine, as measured in 12-hour overnight urine specimens. This relation did not appear to be mediated by smoking or medication use.
呼气峰值流速（PEFR）与老年人的多项健康指标相关，包括身体和认知功能。然而，在非体弱人群中这些关系是否持续尚不清楚。
麦克阿瑟基金会成功老龄化研究网络的社区研究，对从三个总体样本中70至79岁的1354名受试者进行了抽样，使用小型赖特峰值流量计测量PEFR。根据简单的身体和认知功能指标（高 = 1192；中 = 80；低 = 82）选择受试者，并对他们进行了一系列更详细的测试。
经年龄、性别、身高、体重和吸烟因素校正后的残余PEFR与多项身体机能指标高度相关（p <.001），包括串联行走步数、单腿站立秒数、转圈次数、书写自己名字、快速行走10英尺、足部轻拍（每次轻拍时间）和握力。六个身体功能项目组合的关联最为明显。残余PEFR也与认知表现相关，包括相似性、命名、空间识别、记忆和图形绘制测试。综合测量的关联最为显著。这些关联在仅限于“高”功能组以及无既往心肌梗死、中风或癌症病史的分析中仍然存在。残余PEFR与12小时过夜尿液样本中测量的尿去甲肾上腺素也表现出强烈的独立关联。这种关系似乎不受吸烟或药物使用的介导。
