化脓性链球菌侵袭性分离株免疫球蛋白G结合蛋白表达分析
Analysis of immunoglobulin G-binding-protein expression by invasive isolates of Streptococcus pyogenes.
作者信息
Raeder R, Boyle M D
机构信息
Department of Microbiology, Medical College of Ohio, Toledo 43699-0008, USA.
出版信息
Clin Diagn Lab Immunol. 1995 Jul;2(4):484-6. doi: 10.1128/cdli.2.4.484-486.1995.
Abstract
Invasive group A streptococcal isolates collected as part of a Centers for Disease Control and Prevention surveillance study were analyzed for expression of immunoglobulin G (IgG)-binding proteins. Two IgG-binding phenotypes of group A isolates of the M1 serotype were identified. The first group expressed a surface protein that bound all four human IgG subclasses (type IIo) and was recognized by rabbit anti-serotype M1-specific antiserum but not by normal rabbit serum. The second group expressed an IgG-binding protein that was also recognized by the anti-serotype M1 antiserum but demonstrated significant nonimmune reactivity only with human IgG3 (type IIb). Analysis of extracts of the isolates for reactivity with human IgA, fibrinogen, and albumin was also performed. The importance of the binding of human plasma proteins to pathogenic group A streptococci remains to be established.
摘要
作为疾病控制与预防中心监测研究的一部分收集的侵袭性A组链球菌分离株，对其免疫球蛋白G（IgG）结合蛋白的表达进行了分析。鉴定出了M1血清型A组分离株的两种IgG结合表型。第一组表达一种表面蛋白，该蛋白能结合所有四种人IgG亚类（IIo型），并被兔抗M1血清型特异性抗血清识别，但不被正常兔血清识别。第二组表达一种IgG结合蛋白，该蛋白也被抗M1血清型抗血清识别，但仅与人IgG3表现出显著的非免疫反应性（IIb型）。还对分离株提取物与人IgA、纤维蛋白原和白蛋白的反应性进行了分析。人血浆蛋白与致病性A组链球菌结合的重要性仍有待确定。
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