El-Rashidy R, Niazi S
J Pharm Sci. 1979 Jan;68(1):103-4. doi: 10.1002/jps.2600680134.
A highly sensitive and specific GLC method was developed for the analysis of butylated hydroxyanisole, a commonly used antioxidant. Concentrations below 100 ng/ml could be detected in human plasma and urine. Preliminary pharmacokinetic studies demonstrated that, upon administration of 100 mg po, butylated hydroxyanisole was quickly absorbed and removed from the plasma with a high degree of intersubject variability.
开发了一种高灵敏度和特异性的气相色谱法，用于分析常用抗氧化剂丁基羟基茴香醚。在人血浆和尿液中可检测到浓度低于100 ng/ml的该物质。初步药代动力学研究表明，口服100 mg丁基羟基茴香醚后，其吸收迅速，并从血浆中消除，个体间差异很大。
