Umezu T
Regional Environment Division, National Institute for Environmental Studies, Tsukuba, Japan.
Nihon Shinkei Seishin Yakurigaku Zasshi. 1995 Aug;15(4):305-14.
The Vogel-type conflict task, in which drinking of water by animals is punished by electric shock, is well known as a simple conflict procedure, and has come into wide use. This task has almost been established in rats. On the other hand, there are only few reports about application of the task to mice, and such studies have not proceeded smoothly. This report presents technical problems in the application of the task to mice based on various experiments, in which experimental conditions such as procedures, intensity of electric shock and mouse strain differed, in order to determine the anti-conflict action of diazepam (DZ). These experiments showed that successful detection of DZ action depended upon the experimental conditions. Therefore, experimental designs are important in evaluating anti-conflict action of chemicals in the Vogel-type task in mice.
沃格尔型冲突任务是一种简单的冲突程序，即动物饮水会受到电击惩罚，该任务已被广泛应用。此任务在大鼠中几乎已得到确立。另一方面，关于将该任务应用于小鼠的报道很少，且此类研究进展并不顺利。本报告基于各种实验，介绍了将该任务应用于小鼠时存在的技术问题，这些实验的程序、电击强度和小鼠品系等实验条件各不相同，目的是确定地西泮（DZ）的抗冲突作用。这些实验表明，DZ作用的成功检测取决于实验条件。因此，在评估小鼠沃格尔型任务中化学物质的抗冲突作用时，实验设计很重要。
