Tiihonen J, Kuikka J, Bergström K, Hakola P, Karhu J, Ryynänen O P, Föhr J
University of Kuopio, Department of Forensic Psychiatry, Niuvanniemi Hospital, Finland.
Nat Med. 1995 Jul;1(7):654-7. doi: 10.1038/nm0795-654.
Animal studies suggest that development of substance dependence is associated with dopaminergic activity in striatum and the limbic system. Several genetic studies indicate that allele A1 is associated with both D2 receptor density and alcoholism, although these findings have remained controversial. We studied striatal dopamine (DA) re-uptake site densities in 48 subjects (19 healthy controls, 19 habitually impulsive violent alcoholics, and 10 non-violent alcoholics) with single photon emission computed tomography (SPECT) using iodine-123-labelled 2 beta-carbomethoxy-3 beta(4-iodophenyl)tropane, (beta-CIT) as a tracer. Blind quantitative analysis revealed that the striatal DA transporter density was markedly lower in non-violent alcoholics than in healthy controls (P < 0.001), while violent alcoholics had slightly higher DA transporter densities than controls (P < 0.10). The results indicate that both types of alcoholics have alterations in striatal dopaminergic system, though these occur in opposite directions.
动物研究表明，物质依赖的发展与纹状体和边缘系统中的多巴胺能活动有关。多项遗传学研究表明，A1等位基因与D2受体密度及酒精中毒均相关，尽管这些研究结果仍存在争议。我们使用碘-123标记的2β-甲氧基羰基-3β（4-碘苯基）托烷（β-CIT）作为示踪剂，通过单光子发射计算机断层扫描（SPECT）研究了48名受试者（19名健康对照者、19名习惯性冲动暴力酗酒者和10名非暴力酗酒者）纹状体多巴胺（DA）再摄取位点密度。盲法定量分析显示，非暴力酗酒者纹状体DA转运体密度显著低于健康对照者（P < 0.001），而暴力酗酒者的DA转运体密度略高于对照者（P < 0.10）。结果表明，两种类型的酗酒者纹状体多巴胺能系统均有改变，尽管改变方向相反。
