Levy E
Centre de Recherche of Sainte-Justine Hospital, Université de Montréal, Québec.
Can J Cardiol. 1995 Oct;11 Suppl G:29G-35G.
Abundant data from both experimental animals and humans now support the conclusion that the incidence of atherosclerosis is related to the concentration of plasma cholesterol. Cholesterol homeostasis in the body is maintained by regulatory mechanisms, which control the input and output processes. The liver plays a key role in cholesterol balance. In this organ, the major part of the cholesterol synthesis, cholesterol conversion to bile acids and the delivery of cholesterol to the plasma in the form of lipoprotein remnants, low and high density lipoproteins. While many studies have related dietary intake of fatty acids to concentrations of cholesterol in the circulation, their potential effects on liver sterol metabolism have received relatively less attention. However, the liver represents the target of many stimuli capable of affecting cholesterol homeostasis. This review will focus on the regulation of liver sterol metabolism by omega-3 versus omega-6 fatty acids.
动脉粥样硬化的发生率与血浆胆固醇浓度有关。体内胆固醇的稳态是通过调节机制维持的，这些机制控制着输入和输出过程。肝脏在胆固醇平衡中起关键作用。在这个器官中，胆固醇合成的主要部分、胆固醇转化为胆汁酸以及以脂蛋白残粒、低密度和高密度脂蛋白的形式将胆固醇输送到血浆中。虽然许多研究已经将脂肪酸的饮食摄入量与循环中胆固醇的浓度联系起来，但它们对肝脏固醇代谢的潜在影响相对较少受到关注。然而，肝脏是许多能够影响胆固醇稳态的刺激的靶点。这篇综述将聚焦于ω-3脂肪酸与ω-6脂肪酸对肝脏固醇代谢的调节作用。
