Lu Y F, Hattori Y, Moriwaki A, Hayashi Y, Hori Y
Department of Physiology, Okayama University Medical School, Japan.
Can J Physiol Pharmacol. 1995 May;73(5):670-4. doi: 10.1139/y95-086.
Effects of somatostatin (SRIF) on neurons in the medial amygdaloid nucleus were investigated in rat brain slice preparations, using extracellular recordings. Following bath application of SRIF at 10(-7) - 10(-6) M, 63 of 81 (78%) medial amygdala neurons showed an inhibitory response. The inhibitory effect of SRIF was dose dependent, and the threshold concentration was approximately 10(-9) M. The inhibitory response to SRIF persisted during synaptic blockade in two-thirds of neurons tested. The inhibitory effect of SRIF was reduced by picrotoxin, a GABAA receptor antagonist, in one-third of neurons. These results suggest that SRIF exerts an inhibitory effect on medial amygdala neurons through either a direct action on SRIF receptors or a GABAergic synaptic involvement.
