Alderton H R
Division of Child Psychiatry, University of Toronto, Ontario.
Can J Psychiatry. 1995 Aug;40(6):325-9.
To identify the necessity for close monitoring of the QT interval in children and adolescents treated with tricyclics.
Guidelines for permissible ECG changes are reviewed and a case report of a 12-year-old girl with idiopathic long QT syndrome, no history of cardiac disorder, a questionable family history, and normal physical examination and baseline ECG is presented.
Marked increase in QT corrected for heart rate (QTc) occurred on low-dose tricyclic. Possible factors in deaths on desipramine are reviewed.
It is recommended that children and adolescents on tricyclics receive an ECG at baseline and after each dose increase. Recommendations are made regarding ECG parameters and indications for cardiac consultation.
确定对接受三环类药物治疗的儿童和青少年进行QT间期密切监测的必要性。
回顾了关于可允许心电图变化的指南，并报告了一名12岁特发性长QT综合征女孩的病例，该女孩无心脏病史，家族病史存疑，体格检查和基线心电图正常。
低剂量三环类药物治疗时，心率校正后的QT（QTc）显著增加。回顾了地昔帕明致死的可能因素。
建议接受三环类药物治疗的儿童和青少年在基线时以及每次增加剂量后接受心电图检查。针对心电图参数和心脏会诊指征提出了建议。
