Pan Z K, Ikonomidis G, Pardoll D, Paterson Y
Department of Microbiology, University of Pennsylvania, Philadelphia 19104-6076, USA.
Cancer Res. 1995 Nov 1;55(21):4776-9.
We have shown previously that Listeria monocytogenes, a gram-positive, facultative intracellular bacterium, is a potent vector for targeting tumor-specific antigens to the immune system. After parenteral administration, we observed protection against both renal and colorectal mouse tumors and regression of established renal tumors. In the present study, we have exploited the fact that the normal route of infection of this organism is through the gut. We show that an L. monocytogenes recombinant that expresses a model tumor antigen is an effective cancer immunotherapeutic agent when delivered orally in that it causes regression of established, macroscopic mouse renal and colorectal tumors expressing the same antigen.
我们之前已经表明，单核细胞增生李斯特菌是一种革兰氏阳性兼性细胞内细菌，是将肿瘤特异性抗原靶向免疫系统的有效载体。经肠胃外给药后，我们观察到对小鼠肾肿瘤和结肠直肠肿瘤均有保护作用，且已形成的肾肿瘤出现消退。在本研究中，我们利用了这种生物体的正常感染途径是通过肠道这一事实。我们发现，表达一种模型肿瘤抗原的单核细胞增生李斯特菌重组体经口服给药时是一种有效的癌症免疫治疗剂，因为它能使已形成的、表达相同抗原的肉眼可见的小鼠肾肿瘤和结肠直肠肿瘤消退。
