Park T W, Felix J C, Wright T C
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.
Cancer Res. 1995 Nov 1;55(21):4793-6.
Ovarian carcinoma can arise synchronously from multiple independent sites and metastasize widely. Therefore, it is frequently unclear whether bilateral tumors represent two independent primaries or one primary and a metastasis. We have used X chromosome inactivation of the androgen receptor gene and microsatellite instability at four chromosomal loci to evaluate the clonal origin of 39 bilateral ovarian carcinomas. An identical monoclonal pattern was found bilaterally in all cases including 10 stage I bilateral ovarian carcinomas. Microsatellite alterations were identified in three cases, and in all three, identical alterations were present in tumor tissue from both ovaries. These results suggest that bilateral ovarian carcinomas evolve as unifocal neoplasias and that metastatic dissemination can occur early in the course of the disease.
卵巢癌可同时起源于多个独立部位并广泛转移。因此，双侧肿瘤究竟代表两个独立的原发灶还是一个原发灶及一个转移灶常常并不明确。我们利用雄激素受体基因的X染色体失活以及四个染色体位点的微卫星不稳定性来评估39例双侧卵巢癌的克隆起源。在所有病例中，包括10例Ⅰ期双侧卵巢癌，双侧均发现相同的单克隆模式。在三例病例中鉴定出微卫星改变，并且在所有这三例中，双侧卵巢的肿瘤组织中均存在相同的改变。这些结果表明，双侧卵巢癌是作为单灶性肿瘤发生发展的，并且转移播散可能在疾病进程的早期就已发生。
