Freimark D, Matetzky S, Hod H, Chouragui P, Kaplinsky E, Rabinowitz B
Heart Institute, Sheba Medical Center, Tel-Hashomer, Tel-Aviv University, Israel.
Cardiology. 1995;86(5):411-6. doi: 10.1159/000176912.
Successful thrombolysis alters the pattern of creatine kinase (CK) release to the plasma after acute myocardial infarction (AMI). Among the important differences there are the early peak of the CK activity curve and the higher peak value for a given infarct size. To determine whether the magnitude of peak CK following thrombolysis still reflects the extent of myocardial damage, we correlated the peak CK value with left ventricular ejection fraction (LVEF) in 114 patients with first anterior AMI who had early peak CK ( < or = 12 h) after thrombolysis. There was a significant (p < 0.001) linear relation between the peak CK value and LVEF both at admission and 2 months later. High ( > or = 1,500 IU/1) as compared with low early peak CK was associated with significantly lower LVEF (p < 0.001) and a higher incidence of poor LVEF (p < 0.05).
成功的溶栓治疗可改变急性心肌梗死（AMI）后肌酸激酶（CK）向血浆中的释放模式。在重要差异中，有CK活性曲线的早期峰值以及给定梗死面积时更高的峰值。为了确定溶栓后CK峰值的大小是否仍反映心肌损伤程度，我们将114例首次发生前壁AMI且溶栓后CK早期峰值（≤12小时）的患者的CK峰值与左心室射血分数（LVEF）进行了关联分析。入院时及2个月后，CK峰值与LVEF之间均存在显著的（p<0.001）线性关系。与早期低CK峰值相比，高CK峰值（≥1500 IU/1）与显著更低的LVEF（p<0.001）以及LVEF降低的更高发生率（p<0.05）相关。
