Bjørnstad K, Aakhus S, Hatle L
Department of Medicine, University Hospital of Trondheim, Norway.
Cardiology. 1995;86(6):514-20. doi: 10.1159/000176932.
This study compared the diagnostic accuracy of dipyridamole (0.84 mg i.v./10 min) and bicycle stress echocardiography in 37 patients with inconclusive standard bicycle electrocardiography (ECG) tests; all underwent coronary angiography. Sensitivity for detection of coronary stenosis with dipyridamole echocardiography was 68% (21 of 31 patients), and for 1-, 2- and 3-vessel disease 56, 69 and 83%, respectively. Overall bicycle echocardiography sensitivity was 84%, and 78, 88 and 83% for patients with 1-, 2- and 3-vessel disease, respectively. Dipyridamole echocardiography was negative in all 6 patients with negative coronary angiography (specificity 100%), bicycle echocardiography was positive in 2 (specificity 67%). We conclude that dipyridamole echocardiography tends to be less sensitive in patients with mild disease, but is more specific than bicycle echocardiography.
本研究比较了双嘧达莫（静脉注射0.84mg/10分钟）和踏车运动负荷超声心动图对37例标准踏车心电图（ECG）检查结果不明确的患者的诊断准确性；所有患者均接受了冠状动脉造影。双嘧达莫负荷超声心动图检测冠状动脉狭窄的敏感性为68%（31例患者中的21例），对于单支、双支和三支血管病变的敏感性分别为56%、69%和83%。总体而言，踏车运动负荷超声心动图的敏感性为84%，对于单支、双支和三支血管病变患者的敏感性分别为78%、88%和83%。6例冠状动脉造影阴性的患者双嘧达莫负荷超声心动图均为阴性（特异性100%），2例踏车运动负荷超声心动图为阳性（特异性67%）。我们得出结论，双嘧达莫负荷超声心动图对轻度病变患者的敏感性往往较低，但比踏车运动负荷超声心动图更具特异性。
