Arai Y, Mizuguchi M, Ikeda K, Takashima S
Department of Mental Retardation and Birth Defect Research, National Center for Neurology and Psychiatry, Tokyo, Japan.
Brain Res Dev Brain Res. 1995 Jul 14;87(2):228-32. doi: 10.1016/0165-3806(95)00066-m.
The temporal profile of apolipoprotein-E (apo-E) expression was investigated immunohistochemically in the brains of Down syndrome patients and of normal controls. The number of apo-E immunoreactive astrocytes in the frontal cortex was larger in Down syndrome patients than in controls from 7 months to 24 years of age. It suggests that apo-E producing astrocytes in the early phase of pathological process lead to presenile dementia in Down syndrome patients. In contrast, the number in the white matter was smaller in Down syndrome patients from 28 gestational weeks to 5 years. Apo-E immunoreactive senile plaques were noted in Down syndrome brains from the age of 25 years, while APP immunoreactivity was first noted in senile plaques at the age of 32 years.
采用免疫组织化学方法研究了唐氏综合征患者和正常对照者大脑中载脂蛋白E（apo-E）表达的时间变化情况。在7个月至24岁的年龄段，唐氏综合征患者额叶皮质中apo-E免疫反应性星形胶质细胞的数量多于对照组。这表明在病理过程早期产生apo-E的星形胶质细胞导致唐氏综合征患者出现早老性痴呆。相反，在孕28周龄至5岁的唐氏综合征患者中，白质中的细胞数量较少。在25岁的唐氏综合征患者大脑中发现了apo-E免疫反应性老年斑，而淀粉样前体蛋白（APP）免疫反应性最早在32岁的老年斑中被发现。
