Scavalli A S, Spadaro A, Riccieri V, Ricciuti G P, Taccari E, Marini M, Zoppini A
Institute of Rheumatology, University La Sapienza, Rome, Italy.
Clin Rheumatol. 1995 Jul;14(4):481-4. doi: 10.1007/BF02207688.
Idiopathic retroperitoneal fibrosis (RPF) is characterized by the development of a fibrotic mass surrounding the abdominal aorta and its branches, of unknown aetiology. Several immunological mechanisms can be operative in the pathogenesis of RPF. Based on this assumption we treated a patient affected by idiopathic RPF with low-dose methotrexate (MTX) therapy. To our knowledge this is the first example of the effectiveness and safety of a long-term low-dose MTX treatment in the post-surgical management of RPF.
特发性腹膜后纤维化（RPF）的特征是在腹主动脉及其分支周围形成纤维化肿块，病因不明。几种免疫机制可能在RPF的发病机制中起作用。基于这一假设，我们用低剂量甲氨蝶呤（MTX）疗法治疗了一名患有特发性RPF的患者。据我们所知，这是长期低剂量MTX治疗在RPF术后管理中有效性和安全性的首个实例。
