The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin.

Suppr

超能文献

作者信息

Dameron K M, Volpert O V, Tainsky M A, Bouck N

机构信息

Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois 60611, USA.

出版信息

Cold Spring Harb Symp Quant Biol. 1994;59:483-9. doi: 10.1101/sqb.1994.059.01.053.

DOI:10.1101/sqb.1994.059.01.053

PMID:7587102

Abstract

摘要

相似文献

The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin.

Cold Spring Harb Symp Quant Biol. 1994;59:483-9. doi: 10.1101/sqb.1994.059.01.053.

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1.

Science. 1994 Sep 9;265(5178):1582-4. doi: 10.1126/science.7521539.

Tumour suppressor genes and angiogenesis: the role of TP53 in fibroblasts.肿瘤抑制基因与血管生成：TP53在成纤维细胞中的作用

Eur J Cancer. 1996 Dec;32A(14):2394-400. doi: 10.1016/s0959-8049(96)00385-1.

Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1.通过10号染色体诱导血小板反应蛋白-1抑制人胶质母细胞瘤中的血管生成。

Cancer Res. 1996 Dec 15;56(24):5684-91.

The modulation of thrombospondin and other naturally occurring inhibitors of angiogenesis during tumor progression.

Breast Cancer Res Treat. 1995;36(2):119-26. doi: 10.1007/BF00666034.

The p53 mutation "gradient effect" and its clinical implications.p53 突变的“梯度效应”及其临床意义。

J Cell Physiol. 2007 Nov;213(2):370-3. doi: 10.1002/jcp.21217.

Mechanism of functional inactivation of a Li-Fraumeni syndrome p53 that has a mutation outside of the DNA-binding domain.一种李-佛美尼综合征p53在DNA结合域外发生突变后的功能失活机制。

Cancer Res. 2001 Feb 15;61(4):1741-6.

Biochemical and imaging surveillance in Li-Fraumeni syndrome.李-弗劳梅尼综合征的生化与影像学监测

Lancet Oncol. 2016 Nov;17(11):e472. doi: 10.1016/S1470-2045(16)30530-7.

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.一种依赖肿瘤抑制因子的血管生成抑制剂在免疫学和功能上与血小板反应蛋白的一个片段无法区分。

Proc Natl Acad Sci U S A. 1990 Sep;87(17):6624-8. doi: 10.1073/pnas.87.17.6624.

Biochemical and imaging surveillance in Li-Fraumeni syndrome - Authors' reply.李-弗劳梅尼综合征的生化与影像学监测——作者回复

Lancet Oncol. 2016 Nov;17(11):e473. doi: 10.1016/S1470-2045(16)30525-3.

引用本文的文献

Heterogeneity of Extracellular Vesicles and Particles: Molecular Voxels in the Blood Borne "Hologram" of Organ Function, Disfunction and Cancer.细胞外囊泡和颗粒的异质性：血液中器官功能、功能障碍和癌症的“全息图”中的分子体素。

Arch Immunol Ther Exp (Warsz). 2023 Feb 2;71(1):5. doi: 10.1007/s00005-023-00671-2.

pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines.pVHL 介导的抗血管生成蛋白血栓素-1的调节降低了透明细胞肾细胞癌细胞系的迁移。

Sci Rep. 2020 Jan 24;10(1):1175. doi: 10.1038/s41598-020-58137-w.

Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors.针对结直肠癌和其他实体瘤中的致癌性 p53 突变。

Int J Mol Sci. 2019 Nov 28;20(23):5999. doi: 10.3390/ijms20235999.

Antiangiogenic Gene Therapy in Cancer.癌症中的抗血管生成基因治疗。

Curr Genomics. 2000;1(2):117-133. doi: 10.2174/1389202003351535.

Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.细胞外基质降解产物下调肿瘤性食管细胞表型。

Tissue Eng Part A. 2019 Mar;25(5-6):487-498. doi: 10.1089/ten.TEA.2018.0105.

Tumor suppressor protein p53 negatively regulates ischemia-induced angiogenesis and arteriogenesis.肿瘤抑制蛋白p53对缺血诱导的血管生成和动脉生成起负向调节作用。

J Vasc Surg. 2018 Dec;68(6S):222S-233S.e1. doi: 10.1016/j.jvs.2018.02.055. Epub 2018 Aug 17.

Oncosuppressors and Oncogenes: Role in Haemangioma Genesis and Potential for Therapeutic Targeting.抑癌基因和原癌基因：在血管瘤发生中的作用及潜在治疗靶点。

Int J Mol Sci. 2018 Apr 13;19(4):1192. doi: 10.3390/ijms19041192.

Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.突变型p53蛋白与Hippo信号转导分子YAP和TAZ：人类癌症中的关键致癌节点

Int J Mol Sci. 2017 May 3;18(5):961. doi: 10.3390/ijms18050961.

Influence of TP53 Codon 72 Polymorphism Alone or in Combination with HDM2 SNP309 on Human Infertility and IVF Outcome.TP53基因第72位密码子多态性单独或与HDM2基因SNP309联合对人类不孕不育及体外受精结局的影响

PLoS One. 2016 Nov 29;11(11):e0167147. doi: 10.1371/journal.pone.0167147. eCollection 2016.

Thrombospondin-1 as a Paradigm for the Development of Antiangiogenic Agents Endowed with Multiple Mechanisms of Action.血小板反应蛋白-1作为具有多种作用机制的抗血管生成药物研发范例

Pharmaceuticals (Basel). 2010 Apr 23;3(4):1241-1278. doi: 10.3390/ph3041241.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验