Li X, Ran J, Rao H
Second Affiliated Hospital of Shanxi Medical College, Taiyuan.
Zhonghua Fu Chan Ke Za Zhi. 1995 Jul;30(7):410-3.
To study the influence of oral contraceptives on cervical epithelium, serum and red blood cell folate levels of users and to observe the changes after treatment with folic acid.
Morphology of cervical epithelium, serum folate and red blood cell folate levels were studied in 101 women who had used oral contraceptives for over 6 months and 33 intrauterine devices users served as controls, 29 women using oral contraceptives with cervical megaloblastic changes were treated with folic acid (5mg daily) for 3-4 weeks and followed up for observation on morphological changes of cervical epithelium.
The mean nuclear diameter of cervical epithelial cells was larger in the oral contraceptive group than that in the control group (P < 0.001). Megaloblastic changes in cervical epithelium occurred in 29 women in the oral contraceptive group (28.7%). There was significant difference in the occurrence of cervical megaloblastic changes between the two groups (P < 0.01). The level of red blood cell folate was lower in the oral contraceptive group than that in the control group (P < 0.05). There was no difference in serum folate, hemoglobin and neutrophil nuclear index between the two groups (P > 0.05). The mean nuclear diameter of cervical epithelial cells decreased significantly (P < 0.001) and multinuclear and vacuolar changes disappeared after folic acid therapy in 26 women with megaloblastic changes.
Oral contraceptives reduced folate storage in the body and resulted in megaloblastic changes in cervical epithelium. This condition was improved with folic acid therapy.
研究口服避孕药对使用者宫颈上皮、血清及红细胞叶酸水平的影响，并观察叶酸治疗后的变化。
对101名使用口服避孕药超过6个月的女性以及33名使用宫内节育器的女性作为对照，研究其宫颈上皮形态、血清叶酸和红细胞叶酸水平。对29名使用口服避孕药且有宫颈巨幼细胞改变的女性给予叶酸（每日5mg）治疗3 - 4周，并随访观察宫颈上皮的形态变化。
口服避孕药组宫颈上皮细胞的平均核直径大于对照组（P < 0.001）。口服避孕药组有29名女性（28.7%）发生宫颈上皮巨幼细胞改变。两组宫颈巨幼细胞改变的发生率有显著差异（P < 0.01）。口服避孕药组红细胞叶酸水平低于对照组（P < 0.05）。两组血清叶酸、血红蛋白和中性粒细胞核指数无差异（P > 0.05）。26名有巨幼细胞改变的女性经叶酸治疗后，宫颈上皮细胞的平均核直径显著减小（P < 0.001），多核和空泡改变消失。
口服避孕药减少了体内叶酸储存，导致宫颈上皮巨幼细胞改变。叶酸治疗可改善这种情况。
