Hou Y, Song Y
Peking Union Medical College Hospital, Beijing.
Zhonghua Nei Ke Za Zhi. 1995 Apr;34(4):260-2.
To explore the rational treatment program for acute leukemia complicating pregnancy, we carried out a retrospective study of 15 cases of acute leukemia complicating pregnancy and treated with chemotherapy from 1973 to 1993 in the Hematology Ward of PUMC. Review of the cases receiving chemotherapy revealed no harm to the children in cases of late onset and poor prognosis for the children in cases of early onset. However, the overall results seemed to indicate that the earlier the chemotherapy was instituted, the better the outcome will be for the mothers. A protocol is thus proposed with emphasis on the timing of institution of chemotherapy in relation to the course of pregnancy. Briefly, induced abortion followed by combined chemotherapy in early pregnancy and timely combined chemotherapy in mid- and late pregnancy are recommended. Brief cessation of chemotherapy during parturition may be necessary and sufficient supportive measures are needed.
为探索急性白血病合并妊娠的合理治疗方案，我们对1973年至1993年在协和医院血液科接受化疗的15例急性白血病合并妊娠患者进行了回顾性研究。对接受化疗的病例进行回顾发现，发病较晚的病例对胎儿无不良影响，而发病较早的病例胎儿预后较差。然而，总体结果似乎表明，化疗开始得越早，母亲的预后越好。因此，提出了一个方案，重点是化疗开始的时间与妊娠过程的关系。简而言之，建议在妊娠早期进行人工流产后联合化疗，在妊娠中晚期及时进行联合化疗。分娩期间可能需要短暂停止化疗，并且需要充分的支持措施。
