Matković L, Gomez-Sanchez C E, Lantos C P, Cozza E N
Departamento de Química Biológica, Facultad de Cs. Exactas y Naturales-UBA and PRHOM-CONICET, Buenos Aires, Argentina.
Endocr Res. 1995 Feb-May;21(1-2):471-5. doi: 10.3109/07435809509030464.
Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F. competitively inhibited aldosterone formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OHDOC. High concentrations of DOC increased its conversion to 18OHDOC rather than B.
皮质酮（B）和18-羟基-11-脱氧皮质酮（18OHDOC），而非11-脱氧皮质酮（DOC），能特异性地取代与大鼠肾上腺线粒体特异性结合的皮质醇（F）。F竞争性抑制由B、18OHB和18OHDOC生成醛固酮，但不抑制DOC向B或18OHDOC的转化。高浓度的DOC会增加其向18OHDOC而非B的转化。
