Zhou L, Hammer R P
Department of Psychiatry, Tufts University School of Medicine, Boston, MA 02111, USA.
Eur J Pharmacol. 1995 May 24;278(3):271-4. doi: 10.1016/0014-2999(95)00175-k.
The density of mu-opioid receptors is dependent upon the levels of gonadal steroid hormones in the medial preoptic area of ovariectomized female rats. Because the region containing these cyclical mu-opioid receptors is relatively small, autoradiographic analysis of the binding of a saturating concentration of mu-selective radioligand was used to determine whether hormone treatment affects maximal binding capacity of these receptors. The results reveal that gonadal steroid hormones upregulate mu-opioid receptor binding capacity specifically in the medial preoptic area 27 h later, without affecting binding in adjacent brain regions. This suggests that hormones induce a functional increase of medial preoptic area mu-opioid receptors which could serve to regulate reproductive activities.
在去卵巢雌性大鼠的内侧视前区，μ-阿片受体的密度取决于性腺甾体激素的水平。由于含有这些周期性μ-阿片受体的区域相对较小，因此采用对饱和浓度的μ-选择性放射性配体结合进行放射自显影分析，以确定激素治疗是否会影响这些受体的最大结合能力。结果显示，性腺甾体激素在27小时后特异性地上调内侧视前区的μ-阿片受体结合能力，而不影响相邻脑区的结合。这表明激素诱导内侧视前区μ-阿片受体的功能增加，这可能有助于调节生殖活动。
