竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂CGP 37849对大鼠参考记忆和工作记忆任务表现的影响。
Effects of the competitive NMDA receptor antagonist CGP 37849 on performance of reference and working memory tasks by rats.
作者信息
Deacon R M, Rawlins J N
机构信息
Department of Experimental Psychology, University of Oxford, UK.
出版信息
Eur J Pharmacol. 1995 Jul 4;280(2):239-42. doi: 10.1016/0014-2999(95)00255-j.
PMID:7589194
Abstract
The effects of the competitive NMDA receptor antagonist CGP 37849 (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid) were tested in rats performing (1) a nonspatial working memory task, and (2) a reference memory task that was either partly or fully learnt. CGP 37849 attenuated accuracy in all three tests, suggesting that sensorimotor effects may obscure any drug effects on memory itself.
摘要
竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂CGP 37849（DL-(E)-2-氨基-4-甲基-5-膦酰基-3-戊烯酸）的作用，在执行（1）非空间工作记忆任务和（2）部分或完全习得的参考记忆任务的大鼠中进行了测试。CGP 37849在所有三项测试中均降低了准确性，这表明感觉运动效应可能掩盖了药物对记忆本身的任何作用。
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