Wallace D J, Klinenberg J R, Morham D, Berlanstein B, Biren P C, Callis G
Arthritis Rheum. 1979 Jan;22(1):81-6. doi: 10.1002/art.1780220113.
A 73-year-old woman with Felty's syndrome and arthritis mutilans of long duration presented with tophaceous gout. The 7 previously reported cases of coexistent gout and rheumatoid arthritis (RA) are critically reviewed. Possible explanations for the rare coexistence of RA and gout are discussed: if uric acid is an inhibitor of the immune response, then hyperuricemia and gout could protect against development of RA. Conversely, crystalline protein binding may be a critical factor in the pathogenesis of gout, and the presence of abnormal proteins in RA could protect against gout.
一名73岁患有费尔蒂综合征及长期残毁性关节炎的女性患者出现痛风石性痛风。对先前报道的7例痛风与类风湿关节炎（RA）共存的病例进行了严格审查。讨论了RA与痛风罕见共存的可能解释：如果尿酸是免疫反应的抑制剂，那么高尿酸血症和痛风可能预防RA的发生。相反，晶体蛋白结合可能是痛风发病机制中的关键因素，而RA中异常蛋白的存在可能预防痛风。
