Buchner H, Waberski T D, Fuchs M, Wischmann H A, Beckmann R, Rienäcker A
Philips Research Laboratories, Hamburg, Germany.
Exp Brain Res. 1995;104(3):511-8. doi: 10.1007/BF00231985.
Following median nerve stimulation, several monophasic peaks were recorded at the scalp in the 15-18 ms time range. Source analysis, using three different methods, modelled a source near the centre of the head with an orientation towards the activated hemisphere and a peak activity at 16 ms post stimulus. Magnetic recordings detected no signal in this time range, which confirmed a subcortical location of the source. From dipole localization it was not possible to assign the exact origin of the P16 source to either the subthalamic level or the thalamo-cortical radiation, because of the limited spatial resolution at the centre of the spherical head model. An estimate of the conduction velocity of the medial lemniscus pointed towards a subthalamic origin. The P16 source was preserved in two patients with a lesion of the thalamo-cortical radiation and the ventral thalamus. Further evidence for a subthalamic location of P16 was derived from the physical mechanisms generating far-field potentials.
在正中神经刺激后，在头皮上记录到几个单相峰值，时间范围在15 - 18毫秒。使用三种不同方法进行的源分析模拟出一个靠近头部中心的源，其朝向激活的半球，刺激后16毫秒出现峰值活动。磁记录在此时间范围内未检测到信号，这证实了源的皮质下位置。由于球形头部模型中心的空间分辨率有限，从偶极定位无法将P16源的确切起源确定为丘脑底水平或丘脑 - 皮质辐射。内侧丘系传导速度的估计指向丘脑底起源。在两名丘脑 - 皮质辐射和腹侧丘脑病变的患者中，P16源得以保留。P16丘脑底位置的进一步证据来自产生远场电位的物理机制。
