Corboz M, Sanou S, Grimbert F A
Laboratoire de Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, Université Joseph Fourier, La Tronche, France.
Eur Respir J. 1995 Jul;8(7):1122-9. doi: 10.1183/09031936.95.08071122.
We performed pulmonary venous occlusions in order to check the validity of the pulmonary capillary pressure measurements obtained using pulmonary arterial occlusion in the intact animal. The venous and arterial postocclusion pressure profiles were recorded using balloon catheters introduced, respectively, into a left lower lobe vein and into a right pulmonary artery in the anaesthetized open-chest dog. The pressure profiles were fitted by a biexponential function with an early exponential and a late exponential presenting, respectively, a short and a long time constant. We used the zero-time extrapolation of the late slow exponential to obtain an arterial (Pc,ao) and a venous (Pc,vo) estimate of the pulmonary capillary pressure. Each Pc,ao and Pc,vo made it possible to calculate a fractional arterial or venous pressure gradient when referenced to the arteriovenous pressure gradient measured during the occlusion process. In nine dogs, when referenced to the whole lung, the arterial, middle and venous fractional pressure gradients were 37 +/- 11, 10 +/- 6, and 53 +/- 12%, respectively. As the middle fractional pressure gradient is low, we conclude that pulmonary capillary pressure estimates from arterial occlusion are close to the venous occlusion estimates of capillary pressure in the intact dog lung.
我们进行肺静脉闭塞，以检验在完整动物中使用肺动脉闭塞获得的肺毛细血管压力测量值的有效性。使用分别插入麻醉开胸犬左下叶静脉和右肺动脉的球囊导管记录闭塞后静脉和动脉压力曲线。压力曲线用双指数函数拟合，早期指数和晚期指数分别呈现短时间常数和长时间常数。我们使用晚期缓慢指数的零时间外推来获得肺毛细血管压力的动脉（Pc,ao）和静脉（Pc,vo）估计值。当参考闭塞过程中测量的动静脉压力梯度时，每个Pc,ao和Pc,vo都可以计算出动脉或静脉分数压力梯度。在9只犬中，当参考全肺时，动脉、中间和静脉分数压力梯度分别为37±11%、10±6%和53±12%。由于中间分数压力梯度较低，我们得出结论，在完整犬肺中，通过动脉闭塞估计的肺毛细血管压力接近通过静脉闭塞估计的毛细血管压力。
