一个新的基因家族，由于一个快速进化的外显子，其编码的蛋白质结构差异很大。
A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon.
作者信息
Lundwall A, Lazure C
机构信息
Department of Clinical Chemistry, Lund University, Malmö University Hospital, Sweden.
出版信息
FEBS Lett. 1995 Oct 23;374(1):53-6. doi: 10.1016/0014-5793(95)01076-q.
Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.
尽管一级结构存在巨大差异，但本文表明几种主要的精液蛋白是由属于一个共同家族的基因编码的。该家族成员的转录单位被分为三个外显子：第一个编码信号肽，第二个编码分泌蛋白，而第三个外显子仅由3'非翻译核苷酸组成。第一个和第三个外显子在家族成员之间是保守的，但第二个外显子不保守。人类精液凝素I和II、大鼠SVSII、SVSIV、SVSV以及豚鼠GP1和GP2的基因都属于这个基因家族。
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