Fontalin L N
N.F. Gamaleya Research Institute for Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russia.
Folia Biol (Praha). 1994;40(6):371-80.
Data on tolerance of mice to rat tissue grafts obtained during the last 20 years are presented in this article. The method of tolerance induction, which spared recipients' lymphoid tissue and which needed no supporting antigen or immunodepressant injection, is described. These tolerant mice had long-lasting (more than 6 months) xenograft survival, had no cytotoxic antibodies and delayed-type hypersensitivity (DTH) reaction to donor antigens but showed only a partial decrease in the levels of mixed lymphocyte reaction (MLR) and non-cytotoxic antibody production. According to indirect evidence, tolerance arose as a result of clonal deletion and was maintained subsequently by antigen-specific T-suppressor cells and Thy-negative lymphocytes.
本文展示了过去20年里关于小鼠对大鼠组织移植物耐受性的数据。文中描述了诱导耐受性的方法，该方法可保留受体的淋巴组织，且无需注射支持性抗原或免疫抑制剂。这些耐受小鼠的异种移植物存活时间长（超过6个月），对供体抗原无细胞毒性抗体和迟发型超敏反应（DTH），但混合淋巴细胞反应（MLR）水平和无细胞毒性抗体产生仅部分降低。根据间接证据，耐受性是克隆缺失的结果，随后由抗原特异性T抑制细胞和Thy阴性淋巴细胞维持。
