Richardson J W, Anderson F L, Tsagaris T J
Cardiology. 1979;64(1):1-11. doi: 10.1159/000170573.
Hemodynamic data obtained during rest and exercise in 22 patients with aortic stenosis were analyzed. Mean aortic valve gradient for the group did not change significantly during exercise but there was large individual variability. Aortic valve flow increased during exercise in all but 2 patients. There was no correlation between change in gradient and change in flow during exercise. Although the mean calculated aortic valve area for the group did not change significantly during exercise, the calculated area was larger during exercise in most patients. Change in the calculated valve area correlated best with changes in aortic valve flow, left ventricular stroke work index, and the product of left ventricular systolic pressure and stroke volume. This suggests that in some patients there may be a dynamic component to aortic valve obstruction that may vary with changing hemodynamics.
对22例主动脉瓣狭窄患者静息和运动时获得的血流动力学数据进行了分析。该组患者的平均主动脉瓣压差在运动期间无显著变化，但个体差异较大。除2例患者外，所有患者运动时主动脉瓣血流量均增加。运动期间压差变化与血流量变化之间无相关性。尽管该组患者计算得出的平均主动脉瓣面积在运动期间无显著变化，但大多数患者运动时计算得出的面积更大。计算得出的瓣膜面积变化与主动脉瓣血流量变化、左心室每搏功指数以及左心室收缩压与每搏量的乘积相关性最好。这表明，在一些患者中，主动脉瓣梗阻可能存在动态成分，其可能随血流动力学变化而变化。
