Byrd R A, Markham J K, Emmerson J L
Toxicology Research Laboratories, Lilly Research Laboratories, Greenfield, Indiana 46140, USA.
Fundam Appl Toxicol. 1995 Jul;26(2):181-90. doi: 10.1006/faat.1995.1089.
The potential developmental toxicity of trifluralin was evaluated in rats and rabbits. Pregnant rats and rabbits were dosed once daily by gavage on Gestation Days 6-15 and 6-18, respectively. Doses for rats were 0, 100, 225, 475, or 1000 mg/kg; doses for rabbits were 0, 100, 225, or 500 mg/kg. Cesarean sections were performed on rats and rabbits on Gestation Days 20 and 28, respectively. In rats, maternal toxicity was indicated in the 475 and 1000 mg/kg treatment groups by depression of body weights and food consumption. Fetal viability and morphology were not adversely affected at any dose level. Developmental toxicity was indicated at the 1000-mg/kg dose level by depression of fetal weight. The NOAEL for maternal toxicity in the rat was 225 mg/kg; the NOAEL for developmental toxicity in the rat was 475 mg/kg. In rabbits, maternal toxicity was indicated at the 225 and 500 mg/kg dose levels by abortions and/or deaths in conjunction with anorexia and cachexia. Developmental toxicity was indicated at the 500 mg/kg dose level by depressed fetal viability and weight. Fetal morphology was not adversely affected at any dose level. The NOAELs for maternal and developmental toxicity in the rabbit were 100 and 225 mg/kg, respectively. Based on these data, trifluralin did not exhibit selective toxicity toward the developing conceptus.
在大鼠和兔子身上评估了氟乐灵的潜在发育毒性。分别在妊娠第6至15天和第6至18天，对怀孕的大鼠和兔子每天经口灌胃给药一次。大鼠的给药剂量为0、100、225、475或1000 mg/kg；兔子的给药剂量为0、100、225或500 mg/kg。分别在妊娠第20天和第28天对大鼠和兔子进行剖宫产。在大鼠中，475和1000 mg/kg治疗组出现母体毒性，表现为体重和食物摄入量下降。在任何剂量水平下，胎儿的活力和形态均未受到不利影响。在1000 mg/kg剂量水平下，胎儿体重下降表明存在发育毒性。大鼠母体毒性的无观察到有害作用水平（NOAEL）为225 mg/kg；大鼠发育毒性的NOAEL为475 mg/kg。在兔子中，225和500 mg/kg剂量水平出现母体毒性，表现为流产和/或死亡，伴有厌食和恶病质。在500 mg/kg剂量水平下，胎儿活力和体重下降表明存在发育毒性。在任何剂量水平下，胎儿形态均未受到不利影响。兔子母体和发育毒性的NOAEL分别为100和225 mg/kg。基于这些数据，氟乐灵对发育中的胚胎未表现出选择性毒性。
