Pennock J L, Pae W E, Pierce W S, Waldhausen J A
Circulation. 1979 Feb;59(2):275-9. doi: 10.1161/01.cir.59.2.275.
A controlled study was undertaken to quantitate and compare the effect of left ventricular bypass (LVB) and left atrial bypass (LAB on left ventricular infarct volume (LVIV). After baseline studies, the left anterior descending coronary artery in each of 30 mongrel dogs was ligated 1-1.5 cm from its origin. After baseline ischemic studies, control dogs (group 1--10 dogs), LAB dogs (group 2--10 dogs), and LVB dogs (group 3--10 dogs) were monitored for four hours. Final infarct size was determined by the nitroblue tetrazolium staining technique. Heart rate, mean arterial pressure, and total systemic flow (TSF) showed no significant difference between control and left heart bypass groups. In group 1, the LVIV was 27.7 +/- 6.5 g/100 g left ventricle (LV). In group 2, left heart bypass (LHB) flow was 90 +/- 4% of TSF. The pressure time index (PTI) was 2845 +/- 52 mm Hg-sec/min. The PTI demonstrated no significant difference from cntrols. In group 2, LVIV was 22.5 +/- 6.0 g/100 g LV. LVIV was reduced 18.8% from controls (p less than 0.08). In group 2, LHB was complete. Left ventricular decompression (group 3) resulted in a PTI of 328 +/- 76 mm Hg-sec/min. The PTI was significantly different (p less than 0.001) from groups 1 and 2. The LVIV was 12.6 +/- 5.1 g/100 g LV. LVIV was reduced 54.5% from controls (p less than 0.001) and 44.0% from group 2 (p less than 0.001). These results suggest that LVB may be useful, not only in supporting the circulation in the patient with myocardial infarct and cardiogenic shock, but also in limiting infarct size.
进行了一项对照研究，以定量和比较左心室旁路（LVB）和左心房旁路（LAB）对左心室梗死体积（LVIV）的影响。在进行基线研究后，将30只杂种狗的每只的左冠状动脉前降支在其起始处1-1.5厘米处结扎。在进行基线缺血研究后，对对照组狗（第1组 - 10只狗）、LAB组狗（第2组 - 10只狗）和LVB组狗（第3组 - 10只狗）进行4小时监测。通过硝基四氮唑蓝染色技术确定最终梗死面积。心率、平均动脉压和总全身血流量（TSF）在对照组和左心旁路组之间无显著差异。在第1组中，LVIV为27.7±6.5克/100克左心室（LV）。在第2组中，左心旁路（LHB）血流量为TSF的90±4%。压力时间指数（PTI）为2845±52毫米汞柱 - 秒/分钟。PTI与对照组无显著差异。在第2组中，LVIV为22.5±6.0克/100克LV。LVIV比对照组减少了18.8%（p<0.08）。在第2组中，LHB是完全的。左心室减压（第3组）导致PTI为328±76毫米汞柱 - 秒/分钟。PTI与第1组和第2组有显著差异（p<0.001）。LVIV为12.6±5.1克/100克LV。LVIV比对照组减少了54.5%（p<0.001），比第2组减少了44.0%（p<0.001）。这些结果表明，LVB不仅在支持心肌梗死和心源性休克患者的循环方面可能有用，而且在限制梗死面积方面也可能有用。
