钙拮抗剂盐酸依福地平（NZ - 105）对清醒自发性高血压大鼠肾功能的影响。

Effects of efonidipine hydrochloride (NZ-105), a calcium antagonist, on renal function in conscious spontaneously hypertensive rats.

Yotsumoto T, Masuda Y, Shudo C, Sugita H, Yamashita T, Tanaka S

Shiroaka Research Station of Biological Science, Nissan Chemical Industries Ltd., Saitama, Japan.

Gen Pharmacol. 1995 Mar;26(2):333-7. doi: 10.1016/0306-3623(94)00192-p.

Abstract

We investigated the effects of short- and long-term administration of efonidipine hydrochloride (NZ-105), 1,4-dihydropyridine derivative, in conscious spontaneously hypertensive rats (SHR). 2. Oral administration of NZ-105 for 12 weeks caused diuretic and natriuretic effects, which were not attenuated during the experimental period. 3. In the short-term experiment for investigating the mechanism of the diuretic effect, intravenous injection of NZ-105 (0.03 mg/kg of body weight) significantly increased the urine volume (UV), renal plasma flow (RPF) and glomerular filtration rate (GFR). The increment rate of UV and RPF was 105.4 +/- 17.8% and 111.7 +/- 72.8%, respectively, which were larger than the increment rate of GFR (38.5 +/- 14.0%). 4. The diuretic or natriuretic effect of NZ-105 was suggested to be due to both the inhibition of sodium reabsorption and, at least in part, the increase of GFR.

摘要

我们研究了1,4 - 二氢吡啶衍生物盐酸埃夫尼地平（NZ - 105）对清醒自发性高血压大鼠（SHR）短期和长期给药的影响。2. 口服NZ - 105 12周产生利尿和利钠作用，在实验期间这些作用未减弱。3. 在研究利尿作用机制的短期实验中，静脉注射NZ - 105（0.03 mg/kg体重）显著增加尿量（UV）、肾血浆流量（RPF）和肾小球滤过率（GFR）。UV和RPF的增加率分别为105.4±17.8%和111.7±72.8%，大于GFR的增加率（38.5±14.0%）。4. NZ - 105的利尿或利钠作用被认为是由于抑制钠重吸收以及至少部分由于GFR增加所致。