Gunde-Cimerman N, Plemenitas A, Cimerman A
National Institute of Chemistry, Ljubljana, Slovenia.
FEMS Microbiol Lett. 1995 Oct 1;132(1-2):39-43. doi: 10.1111/j.1574-6968.1995.tb07807.x.
Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese hamster ovary cells. Identification of the inhibitors was studied by thin layer chromatography, high pressure liquid chromatography and mass spectroscopy.
对不同酵母菌种的筛选表明，它们能够合成羟甲基戊二酰辅酶A（HMGCoA）还原酶抑制剂。对来自巴氏毕赤酵母和龋木念珠菌的粗甲醇提取物及纯化抑制剂，检测了其对中国仓鼠卵巢细胞溶解微粒体HMGCoA还原酶的生物活性。通过薄层色谱法、高压液相色谱法和质谱法对抑制剂进行了鉴定研究。
