Mglinets V A
Genetika. 1995 Aug;31(8):1147-53.
A comparative analysis of dermatoglyphic prints of patients with the Holt-Oram syndrome and isolated triphalangeal thumbs was performed with control dermatoglyphics. A specific feature of the syndrome is a change in the main palmar lines and their termination on the radial border of the hand not only in the absence of the thumb but also in the case of formation of the abortive xT-line, its radiants, and the axial triradius. This trait may be considered diagnostic for the Holt-Oram syndrome. Cases of triphalangeal thumbs with preaxial polydactyly do not reveal significant changes in dermatoglyphic patterns and appear to result from partial duplication of the thumb. An isolated triphalangeal thumb may be the result of an atavistic development of homeotic transformation of the thumb.
对患有 Holt-Oram 综合征和孤立性三节指骨拇指的患者的皮纹印与对照皮纹进行了比较分析。该综合征的一个特定特征是主要掌纹的改变及其在手的桡侧缘的终止，不仅在拇指缺如的情况下，而且在出现发育不全的 xT 线、其射线和轴三叉点的情况下也是如此。这一特征可被视为 Holt-Oram 综合征的诊断依据。伴有轴前多指畸形的三节指骨拇指病例未显示皮纹模式有显著变化，似乎是拇指部分重复所致。孤立性三节指骨拇指可能是拇指同源异型转化的返祖发育结果。
