Stanojević-Bakić N, Vucković-Dekić Lj, Inić M, Tomin R
Institute of Oncology and Radiology, Beograd.
Glas Srp Akad Nauka Med. 1994(44):71-82.
We investigated the influence of the natural interferon alpha (IFN-alpha) on the nonspecific immune competence in the early stage of breast cancer. The IFN therapy, which started one month after surgery, lasted four months. Control group of patients received no therapy after surgical removal of the tumor. The immunological parameters (the number and function of T and B cells and mononuclear phagocytes) were monitored once a month during five months. In the course of IFN therapy the values of total and active T cells, as well as their proliferative response to PHA, were slightly decreased, while the number of mononuclear phagocytes and their activity was increased. These values returned into normal range at the end of monitoring. Only the phagocyting activity remained at high level. There was no significant difference between two groups of patients, indicating no effect of IFN therapy on the immunological parameters tested.
我们研究了天然α干扰素（IFN-α）对乳腺癌早期非特异性免疫能力的影响。IFN治疗在手术后一个月开始，持续四个月。对照组患者在手术切除肿瘤后未接受治疗。在五个月期间每月监测一次免疫参数（T细胞、B细胞和单核吞噬细胞的数量和功能）。在IFN治疗过程中，总T细胞和活性T细胞的值及其对PHA的增殖反应略有下降，而单核吞噬细胞的数量及其活性增加。在监测结束时，这些值恢复到正常范围。只有吞噬活性保持在高水平。两组患者之间没有显著差异，表明IFN治疗对所测试的免疫参数没有影响。
