Maruyama K, Watanabe H, Shiozaki H, Takayama T, Gofuku J, Yano H, Inoue M, Tamura S, Raz A, Monden M
Department of Surgery II, Osaka University Medical School, Japan.
Int J Cancer. 1995 Oct 20;64(5):316-21. doi: 10.1002/ijc.2910640506.
Autocrine motility factor and its receptor (gp78) have been shown to play an important role in tumor cell migration, invasion and metastasis. We have detected gp78 expression in buffered-formalin-fixed, paraffin-embedded sections of esophageal squamous cell carcinomas using an anti-gp78 monoclonal antibody (MAb), 3F3A, and examined the relationship between gp78 expression and clinicopathological and prognostic factors. In 55 of 101 (54%) patients, gp78 was detected in the tumor cells. The frequency of gp78-positive expression was significantly associated with tumor size, infiltrative growth, depth of invasion and lymph node metastasis. The cumulative survival rate of patients with gp78 was significantly lower than that of patients without gp78. Our results suggest that autocrine motility factor receptor (gp78) expression could be a useful biomarker for malignancy grading and prognosis in patients with esophageal squamous cell carcinoma.
自分泌运动因子及其受体（gp78）已被证明在肿瘤细胞迁移、侵袭和转移中起重要作用。我们使用抗gp78单克隆抗体（MAb）3F3A检测了食管鳞状细胞癌经缓冲福尔马林固定、石蜡包埋切片中的gp78表达，并研究了gp78表达与临床病理及预后因素之间的关系。在101例患者中的55例（54%）肿瘤细胞中检测到了gp78。gp78阳性表达频率与肿瘤大小、浸润性生长、浸润深度及淋巴结转移显著相关。有gp78患者的累积生存率显著低于无gp78患者。我们的结果表明，自分泌运动因子受体（gp78）表达可能是食管鳞状细胞癌患者恶性程度分级和预后的有用生物标志物。
