Makawiti D W, Lomo P O, Konji V N, Oloowokere J O
Department of Biochemistry, University of Nairobi, Kenya.
Int J Vitam Nutr Res. 1995;65(2):132-6.
The plasma triiodothyronine (T3) and thyroxine (T4) ratios have been evaluated in kwashiorkor and diet-induced obese weaned rats. The concentrations of T3 and T4 were determined in plasma by radio-immunoassay. A significant decrease in T3 level in the order kwashiorkor < obese < control was observed. However T4 concentration was more elevated (P < 0.01) in the obese than the normal controls, while more significantly depressed (P < 0.001) in the kwashiorkor than in control animals. The T3/T4 ratio decreased in the order obese < kwashiorkor < control. It was concluded from these studies that kwashiorkor and diet-induced obesity not only interfere with the absolute concentration of the thyroid hormones but also alter the T3/T4 ratio. The altered T3 and T4 ratio perhaps contributes to the maintenance of the isoenergetic state rather than to the promotion of negative or positive energy balance in kwashiorkor and obese subjects respectively.
对夸休可尔症和饮食诱导肥胖断奶大鼠的血浆三碘甲状腺原氨酸（T3）和甲状腺素（T4）比值进行了评估。采用放射免疫分析法测定血浆中T3和T4的浓度。观察到T3水平按夸休可尔症＜肥胖＜对照的顺序显著降低。然而，肥胖组的T4浓度比正常对照组更高（P＜0.01），而夸休可尔症组的T4浓度比对照组动物显著更低（P＜0.001）。T3/T4比值按肥胖＜夸休可尔症＜对照的顺序降低。从这些研究得出的结论是，夸休可尔症和饮食诱导的肥胖不仅会干扰甲状腺激素的绝对浓度，还会改变T3/T4比值。T3和T4比值的改变可能有助于维持能量平衡状态，而不是分别促进夸休可尔症和肥胖受试者的负能量或正能量平衡。
