Garattini S
Instituto de Richerche Farmacologiche Mario Negri.
Int J Technol Assess Health Care. 1995 Summer;11(3):417-27. doi: 10.1017/s0266462300008643.
Pharmaceutical prescriptions are quite different in four European countries: Italy, France, Germany, and the United Kingdom. In particular, in 1992, among the 50 most sold products by value, only seven active principles are common to these four countries. In Italy, in 1994, there has been a substantial change in pharmaceutical prescriptions, since, for the first time, drugs have been reimbursed by the National Health System (NHS) on the basis of efficacy. As a result of this new policy, the 50 most-sold products by value have changed dramatically in the first five months of 1994. The pharmacologic and economic implications of this change are discussed.
四个欧洲国家（意大利、法国、德国和英国）的药品处方差异很大。特别是在1992年，按价值计算销量最高的50种产品中，这四个国家只有7种活性成分是相同的。在意大利，1994年药品处方发生了重大变化，因为国家卫生系统（NHS）首次根据疗效对药品进行报销。这项新政策实施后，1994年头五个月按价值计算销量最高的50种产品发生了巨大变化。本文讨论了这一变化的药理和经济影响。
