Erton M L, Ilker Y N, Ceyhan N, Akdaş A
Department of Urology, Marmara University School of Medicine, Istanbul, Turkey.
Int Urol Nephrol. 1995;27(2):147-50. doi: 10.1007/BF02551311.
Retroperitoneal fibrosis is idiopathic in two thirds of cases and is found most commonly as an isolated fibrotic plaque centered over the lumbar spine and entrapping one or both ureters. It has been postulated that fibrosis in the idiopathic cases results from a hypersensitivity reaction to antigens leaking into the retroperitoneum from atheromatous plaques in the aorta or common iliac arteries. In the remaining one third of cases, causes include ergot-derivative drugs, retroperitoneal haemorrhage or urine extravasation, and a desmoplastic response to a variety of tumours.
三分之二的病例中，腹膜后纤维化病因不明，最常见的表现是在腰椎水平出现孤立的纤维斑块，包绕一侧或双侧输尿管。据推测，特发性病例中的纤维化是由于对从主动脉或髂总动脉粥样斑块渗漏至腹膜后的抗原产生超敏反应所致。其余三分之一的病例病因包括麦角衍生药物、腹膜后出血或尿液外渗，以及对各种肿瘤的促纤维增生反应。
