Zhang W, Hahn R G, You G, Xu Z
Department of Anaesthesiology, Stockholm Södra Hospital, Sweden.
Int Urol Nephrol. 1995;27(2):167-72. doi: 10.1007/BF02551314.
We studied ultrastructural alterations caused by intravenous infusion of 150 ml/kg of irrigating fluid containing mannitol and/or sorbitol in 15 rabbits. The osmolality of the solutions varied between 165 and 350 mosmol/kg. Specimens for electron microscopic examination were obtained from the kidney, brain and lung. Regardless of the choice of solute, the hypo-osmotic solutions caused damage to kidney and brain tissue by inducing marked interstitial and cellular oedema. No such changes were observed after administration of isosmotic irrigating fluid. We conclude that ultrastructural changes following overhydration with irrigating fluid vary with the osmolality of the solution but not with the choice of solute. Moreover, the consistent absence of tissue damage in the lungs suggests that the lung is not a primary target organ for the "TUR syndrome".
我们研究了给15只兔子静脉输注150毫升/千克含甘露醇和/或山梨醇的冲洗液所引起的超微结构改变。这些溶液的渗透压在165至350毫渗摩尔/千克之间变化。用于电子显微镜检查的标本取自肾脏、大脑和肺。无论溶质的选择如何，低渗溶液通过引起明显的间质和细胞水肿对肾脏和脑组织造成损害。输注等渗冲洗液后未观察到此类变化。我们得出结论，冲洗液过度水化后的超微结构变化随溶液的渗透压而变化，但不随溶质的选择而变化。此外，肺部始终未出现组织损伤，这表明肺不是“经尿道前列腺电切综合征”的主要靶器官。
