Mutani R, Cantello R, Gianelli M, Civardi C
Cattedra di Neurologia, Università di Torino, Facoltà di Medicina e Chirurgia di Novara.
Ital J Neurol Sci. 1995 May;16(4):217-22. doi: 10.1007/BF02282992.
This paper analyzes the effect of conventional (phenobarbital, phenytoin, carbamazepine, ethosuximide, valproate) and some novel (vigabatrin, lamotrigine, felbamate) AEDs on some basic mechanisms involved in focal and/or generalized epileptogenesis (Na+ voltage-dependent channels and sustained repetitive firing, L-, N-, and T-type Ca2+ currents, GABA-mediated inhibition, Glu/Asp-mediated excitation, after-hyperpolarization). According to this analysis, AEDs can be divided into two main categories, those with only one specific action and those with multiple actions. A speculative correlation is proposed between AED effects on the mechanism of epileptogenesis and their known clinical effect on seizures.
本文分析了传统抗癫痫药物（苯巴比妥、苯妥英、卡马西平、乙琥胺、丙戊酸盐）以及一些新型抗癫痫药物（氨己烯酸、拉莫三嗪、非氨酯）对局灶性和/或全身性癫痫发生过程中涉及的一些基本机制（钠电压依赖性通道与持续重复放电、L型、N型和T型钙电流、γ-氨基丁酸介导的抑制作用、谷氨酸/天冬氨酸介导的兴奋作用、后超极化）的影响。根据这一分析，抗癫痫药物可分为两大类，即具有单一特定作用的药物和具有多种作用的药物。文中提出了抗癫痫药物对癫痫发生机制的作用与其对癫痫发作的已知临床疗效之间的一种推测性关联。
