• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The positive nuclear staining observed with monoclonal antibody against PRAD1/cyclin D1 correlates with mRNA expression in mantle cell lymphoma.用抗PRAD1/细胞周期蛋白D1单克隆抗体观察到的阳性核染色与套细胞淋巴瘤中的mRNA表达相关。
Jpn J Cancer Res. 1995 Sep;86(9):890-8. doi: 10.1111/j.1349-7006.1995.tb03102.x.
2
Immunostaining of PRAD1/cyclin D1 protein as a marker for the diagnosis of mantle cell lymphoma.PRAD1/细胞周期蛋白D1蛋白免疫染色作为套细胞淋巴瘤诊断标志物
Leukemia. 1997 Apr;11 Suppl 3:536-7.
3
Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma.细胞周期蛋白D1蛋白分析在套细胞淋巴瘤诊断中的应用
Blood. 1995 Oct 1;86(7):2715-23.
4
Cyclin D1 (Bcl-1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia.细胞周期蛋白D1（Bcl-1、PRAD1）在低度B细胞淋巴瘤和反应性增生中的蛋白表达
Am J Pathol. 1994 Jul;145(1):86-96.
5
Monoclonal antibody against PRAD1/cyclin D1 stains nuclei of tumor cells with translocation or amplification at BCL-1 locus.针对PRAD1/细胞周期蛋白D1的单克隆抗体可对BCL-1基因座发生易位或扩增的肿瘤细胞核进行染色。
Jpn J Cancer Res. 1994 Sep;85(9):918-26. doi: 10.1111/j.1349-7006.1994.tb02969.x.
6
Clinicopathologic study of PRAD1/cyclin D1 overexpressing lymphoma with special reference to mantle cell lymphoma. A distinct molecular pathologic entity.PRAD1/细胞周期蛋白D1过表达淋巴瘤的临床病理研究，特别提及套细胞淋巴瘤。一种独特的分子病理实体。
Am J Surg Pathol. 1996 Sep;20(9):1110-22. doi: 10.1097/00000478-199609000-00009.
7
PRAD1/Cyclin D1 gene overexpression in mantle cell lymphoma.
Leuk Lymphoma. 1996 Mar;21(1-2):37-42. doi: 10.3109/10428199609067577.
8
Expression of cyclin D1 protein in centrocytic/mantle cell lymphomas with and without rearrangement of the BCL1/cyclin D1 gene.BCL1/细胞周期蛋白D1基因有无重排的中心细胞性/套细胞淋巴瘤中细胞周期蛋白D1蛋白的表达
Hum Pathol. 1995 Sep;26(9):999-1004. doi: 10.1016/0046-8177(95)90090-x.
9
Expression of retinoblastoma gene product (pRb) in mantle cell lymphomas. Correlation with cyclin D1 (PRAD1/CCND1) mRNA levels and proliferative activity.视网膜母细胞瘤基因产物（pRb）在套细胞淋巴瘤中的表达。与细胞周期蛋白D1（PRAD1/CCND1）mRNA水平及增殖活性的相关性。
Am J Pathol. 1996 May;148(5):1591-600.
10
Cyclin D1 immunohistochemical staining is useful in distinguishing mantle cell lymphoma from other low-grade B-cell neoplasms in bone marrow.细胞周期蛋白D1免疫组织化学染色有助于在骨髓中鉴别套细胞淋巴瘤与其他低级别B细胞肿瘤。
Am J Clin Pathol. 1997 Sep;108(3):302-7. doi: 10.1093/ajcp/108.3.302.

引用本文的文献

1
Genomic profiles in B cell lymphoma.B 细胞淋巴瘤的基因组图谱。
Int J Hematol. 2010 Sep;92(2):238-45. doi: 10.1007/s12185-010-0662-1. Epub 2010 Aug 27.
2
Cyclin D1 expression is useful as a prognostic indicator for advanced esophageal carcinomas, but not for superficial tumors.
Dig Dis Sci. 2000 May;45(5):864-9. doi: 10.1023/a:1005552419905.
3
Overexpression of cyclin D1 mRNA in colorectal carcinomas and relationship to clinicopathological features: an in situ hybridization analysis.结直肠癌中细胞周期蛋白D1 mRNA的过表达及其与临床病理特征的关系：原位杂交分析
Pathol Oncol Res. 2000;6(1):65-70. doi: 10.1007/BF03032661.
4
Cyclin D1 and human neoplasia.细胞周期蛋白D1与人类肿瘤
Mol Pathol. 1998 Feb;51(1):1-7. doi: 10.1136/mp.51.1.1.
5
Abnormal expression of CCND1 and RB1 in resection margin epithelia of lung cancer patients.肺癌患者手术切缘上皮中CCND1和RB1的异常表达。
Br J Cancer. 1997;75(12):1761-8. doi: 10.1038/bjc.1997.300.

本文引用的文献

1
Rearrangement and overexpression of the BCL-1/PRAD-1 gene in intermediate lymphocytic lymphomas and in t(11q13)-bearing leukemias.BCL-1/PRAD-1基因在中间淋巴细胞淋巴瘤和携带t(11q13)的白血病中的重排与过表达。
Blood. 1993 Jun 1;81(11):3063-7.
2
Multiple breakpoints within the BCL-1 locus in B-cell lymphoma: rearrangements of the cyclin D1 gene.B细胞淋巴瘤中BCL-1基因座内的多个断点：细胞周期蛋白D1基因的重排。
Cancer Res. 1993 Sep 15;53(18):4148-52.
3
Overexpression of PRAD1 in a mantle zone lymphoma patient with a t(11;22)(q13;q11) translocation.
Br J Haematol. 1993 Oct;85(2):427-9. doi: 10.1111/j.1365-2141.1993.tb03194.x.
4
A cell cycle regulator potentially involved in genesis of many tumor types.一种可能参与多种肿瘤类型发生的细胞周期调节因子。
Science. 1994 Apr 15;264(5157):436-40. doi: 10.1126/science.8153634.
5
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers.多种人类癌症中细胞周期蛋白依赖性激酶4抑制剂基因的缺失。
Nature. 1994 Apr 21;368(6473):753-6. doi: 10.1038/368753a0.
6
Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.通过免疫组织化学染色检测乳腺癌中细胞周期蛋白D1的扩增和过表达。
Cancer Res. 1994 Apr 1;54(7):1812-7.
7
Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines.细胞周期蛋白D1在人类肿瘤细胞系中呈振荡变化，对细胞周期进程至关重要。
Oncogene. 1994 Mar;9(3):707-18.
8
A variant chromosome translocation at 11q13 identifying PRAD1/cyclin D1 as the BCL-1 gene.在11q13处的一种变异染色体易位，将PRAD1/细胞周期蛋白D1鉴定为BCL-1基因。
Blood. 1994 Aug 15;84(4):1226-31.
9
Monoclonal antibody against PRAD1/cyclin D1 stains nuclei of tumor cells with translocation or amplification at BCL-1 locus.针对PRAD1/细胞周期蛋白D1的单克隆抗体可对BCL-1基因座发生易位或扩增的肿瘤细胞核进行染色。
Jpn J Cancer Res. 1994 Sep;85(9):918-26. doi: 10.1111/j.1349-7006.1994.tb02969.x.
10
Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age.细胞周期蛋白与癌症。II：细胞周期蛋白D和细胞周期蛋白依赖性激酶抑制剂走向成熟。
Cell. 1994 Nov 18;79(4):573-82. doi: 10.1016/0092-8674(94)90543-6.

用抗PRAD1/细胞周期蛋白D1单克隆抗体观察到的阳性核染色与套细胞淋巴瘤中的mRNA表达相关。

The positive nuclear staining observed with monoclonal antibody against PRAD1/cyclin D1 correlates with mRNA expression in mantle cell lymphoma.

作者信息

Kuroda H, Komatsu H, Nakamura S, Niitsu Y, Takahashi T, Ueda R, Seto M

机构信息

Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya.

出版信息

Jpn J Cancer Res. 1995 Sep;86(9):890-8. doi: 10.1111/j.1349-7006.1995.tb03102.x.

DOI:10.1111/j.1349-7006.1995.tb03102.x
PMID:7591969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5920932/
Abstract

Recently, we produced a monoclonal antibody, 5D4, against the PRAD1/cyclin D1 product and suggested positive nuclear staining to be associated with mantle cell lymphoma (MCL). Now we have further characterized the specificity of this antibody and studied the relation of immunohistochemical detection to PRAD1/cyclin D1 mRNA expression and DNA rearrangement. Immunofluorescence and immunoblotting studies demonstrated the 5D4 antibody to be crossreactive with cyclin D2, but not cyclin D3. On immunostaining, 15 of 19 MCL cases (79%) presented the nuclear staining pattern and PRAD1/cyclin D1 mRNA expression was detected by Northern blot analysis in 12 of 15 MCL cases studied (80%): all cases with the mRNA expression showed the nuclear staining pattern. Southern blot analysis with 11q13 BCL-1 probes detected DNA rearrangements in 8 of 19 MCL cases (42%), all 8 exhibiting PRAD1/cyclin D1 mRNA expression. In 21 lymphoma cases of types other than MCL, neither the mRNA expression nor the nuclear staining were observed, although cytoplasmic staining was often apparent. These results indicated that positive nuclear staining of lymphoma cells by 5D4 antibody reflects PRAD1/cyclin D1 mRNA expression, and showed that this monoclonal antibody has diagnostic value for differentiating MCL from other types of lymphomas.

摘要

最近，我们制备了一种针对PRAD1/细胞周期蛋白D1产物的单克隆抗体5D4，并指出细胞核阳性染色与套细胞淋巴瘤（MCL）相关。现在我们进一步鉴定了该抗体的特异性，并研究了免疫组化检测与PRAD1/细胞周期蛋白D1 mRNA表达及DNA重排之间的关系。免疫荧光和免疫印迹研究表明，5D4抗体与细胞周期蛋白D2有交叉反应，但与细胞周期蛋白D3无交叉反应。在免疫染色中，19例MCL病例中有15例（79%）呈现细胞核染色模式，在15例研究的MCL病例中有12例（80%）通过Northern印迹分析检测到PRAD1/细胞周期蛋白D1 mRNA表达：所有有mRNA表达的病例均呈现细胞核染色模式。用11q13 BCL-1探针进行Southern印迹分析，在19例MCL病例中有8例（42%）检测到DNA重排，所有8例均有PRAD1/细胞周期蛋白D1 mRNA表达。在21例非MCL类型的淋巴瘤病例中，未观察到mRNA表达和细胞核染色，尽管细胞质染色常常很明显。这些结果表明，5D4抗体对淋巴瘤细胞的细胞核阳性染色反映了PRAD1/细胞周期蛋白D1 mRNA表达，并表明该单克隆抗体对鉴别MCL与其他类型淋巴瘤具有诊断价值。