Tulunay F C, Yano I, Takemori A E
Eur J Pharmacol. 1979 Jan 15;53(3):247-53. doi: 10.1016/0014-2999(79)90130-4.
When various biogenic amine modifying drugs were administered to mice which were pretreated with morphine, none of the drugs except atropine and haloperidol altered the usual doubling of the naloxone efficacy which is observed in morphine-pretreated mice. Atropine appeared to decrease the potency of naloxone. Haloperidol, which did not alter naloxone potency in normal mice, further increased the naloxone potency in morphine-pretreated mice. When the biogenic amine modifiers were injected chronically to mice during the development of morphine tolerance, again none of the drugs, except haloperidol and atropine altered the development of tolerance. Haloperidol appeared to enhance and atropine to inhibit the degree of tolerance. These results indicate that it is the alteration in the narcotic-induced enhancement of naloxone potency and not the mere alteration of noloxone potency by various drugs, which can be used as an indicator of the alterations in the development of tolerance.
当给预先用吗啡处理过的小鼠施用各种生物胺修饰药物时，除了阿托品和氟哌啶醇外，没有一种药物能改变预先用吗啡处理过的小鼠中通常观察到的纳洛酮效力加倍的情况。阿托品似乎降低了纳洛酮的效力。氟哌啶醇在正常小鼠中不改变纳洛酮效力，但在预先用吗啡处理过的小鼠中进一步增加了纳洛酮效力。当在吗啡耐受性形成过程中对小鼠长期注射生物胺修饰剂时，同样除了氟哌啶醇和阿托品外，没有一种药物能改变耐受性的形成。氟哌啶醇似乎增强了耐受性程度，而阿托品则抑制了耐受性程度。这些结果表明，可作为耐受性形成变化指标的是麻醉诱导的纳洛酮效力增强的变化，而不是各种药物对纳洛酮效力的单纯改变。
